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When handling this substance appropriate precautions must be taken. See actual entry in RTECS for complete information. See WARNINGS, PRECAUTIONS: DRUG INTERACTIONS, PRECAUTIONS: Laboratory Tests and ADVERSE REACTIONS sections. Imuran tablets (azathioprine 25mg, 50mg) 2. If the film-coated tablet has to be halved, contact of the skin with tablet dust or the broken area must be avoided (see section 4.2 and 6.6). Cytotoxic precautions are the ways that your healthcare team protects themselves from cytotoxic medications or body wastes. The following groups of products are not listed on the WRHA Cytotoxic and Non-Cytotoxic Hazardous Medications list, but may require handling precautions for safe administration. Metabolism pathway of azathioprine: competing pathways result in inactivation by TPMT or XO, or incorporation of cytotoxic nucleotides into DNA. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. SAFETY DATA SHEET SECTION 6: ACCIDENTAL RELEASE MEASURES ... homograft recipients treated with azathioprine. Although the risk of harm may be very low, it is important to be careful. PHARMACEUTICAL FORM . 25mg: Orange tablet, film coated, round, biconvex, unscored, branded GX … As with all cytotoxic chemotherapy, adequate contraceptive precautions should be advised when either partner is receiving Azathioprine AN. 3. 1. All listed drugs are considered hazardous, but safe-handling precautions can vary with the See WARNINGS, PRECAUTIONS: Drug Interactions, PRECAUTIONS: Laboratory Tests and ADVERSE REACTIONS sections. Given the addition of new drug formulations and drugs in tablet and/or capsule form to the list, no single approach can cover the diverse potential occupational exposures to the drugs. For the full list of excipients, see section 6.1. Each tablet contains 25mg, 50 mg azathioprine BP. This is not an estimate of the half-life of azathioprine itself, but is the decay rate for all 35 S-containing metabolites of the drug. Azathioprine is mutagenic and potentially carcinogenic. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (). Salts, pegylated and liposomal drugs: only the parent compound is listed, handle all derivatives of a hazardous drug the same as the parent compound. Figure 1 : Metabolism pathway of azathioprine: competing pathways result in inactivation by TPMT or XO, or incorporation of cytotoxic nucleotides into DNA. PRECAUTIONS FOR FIREFIGHTERS Last Revision: 05/2018 AZATHIOPRINE, USP Page 2 of 8. Maximum serum radioactivity occurs at 1 to 2 hours after oral 35 S-azathioprine and decays with a half-life of 5 hours. Azathioprine is a purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is well absorbed following oral administration. Figure 1. QUALITATIVE AND QUANTITATIVE COMPOSITION . These precautions are only needed when handling your medication or body fluids. This should be especially considered in pregnant nurses (see section 6.6). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. Cytotoxic drugs have also been associated with negative health effects for developing fetuses, including higher Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP … Azathioprine - Investigated as a drug, mutagen, reproductive effector, and tumorigen. tions (universal precautions) be taken in handling hazardous drugs. Carcinogenicity. Either partner is receiving azathioprine AN, see section 6.6 ) hazardous, but safe-handling can. 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